Discover the next generation of startups.

Enjamb Labs

YCombinator

Where drug teams run their entire program, discovery to FDA approval

Enjamb runs the entire drug program for biopharma teams, from discovery to FDA approval. Pharma runs on decades of closed legacy systems like Benchling, Veeva, Medidata, and SAS, with no AI layer and no MCP to connect agents to them. So we built that connection layer in one platform. Our agents run on top of their existing systems and data, with no migration, and do the work across the whole program: clinical evidence, trial design, statistical programming, and regulatory submissions. In just 3 weeks since launch, we're already being used by 500+ employees at top pharma companies, including Johnson & Johnson, AbbVie, Bristol Myers Squibb, Merck & Sanofi.

Envariant

YCombinator

Interpretability and reasoning infra for foundation models.

Envariant is an AI interpretability and reasoning SDK enabling foundation model builders to analyze, steer, and control their model's behaviors.

Eos AI

YCombinator

Autonomous OS for healthcare

Eos helps clinics turn their data into actionable insights to identify more eligible patients and early care interventions. We harmonize historical data across all systems to create standardized patient data distributions, acting like a translation layer between different applications. Then we build a centralized index over it: a compressed representation that lets petabytes of raw data stay where it is while allowing us to search and reason across it as one system. Instead of treating the visit or document as an isolated instance, we can look at it as a continuous story. We can predict how a case will resolve, trigger the required approvals and actions, and do so while reducing staff workload and recovering hospital revenue.

EquipmentShare

YCombinator

Cloud solutions for the construction industry.

EquipmentShare delivers cloud solutions for the construction industry. We provide a better equipment rental experience, fleet tracking software and hardware security solutions to help contractors work smarter.

Estimote, Inc.

YCombinator

Location intelligence platform

Estimote, Inc. is the creator of SpaceTimeOS, a revolutionary operating system installed directly on physical spaces to make them programmable and interactive. Small sensors are attached to walls and items. They talk to each other and communicate with with servers. A digital copy of the physical space is created in the cloud, allowing for inch-precise and real-time tracking of assets, people, and vehicles. When they move or interact with each other pre-programmed actions are triggered as defined in the apps "installed" in different rooms or places. Apps can be downloaded from the marketplace of create by developers using JavaScript and a robust API. The system utilizes wireless technologies such as Bluetooth and Ultra Wideband to automate processes and track the movement of objects. SpaceTimeOS allows for the creation of smart workplace applications and the digital twinning of entire businesses and supply chains, as well as the blending of physical and digital data.

Etleap

YCombinator

Etleap is an ETL solution for creating perfect data pipelines.

Etleap is an ETL solution for creating perfect data pipelines from day one. Unlike other enterprise solutions, Etleap doesn’t require extensive engineering work to set up, maintain, and scale. It automates most ETL setup and maintenance work, and simplifies the rest into 10-minute tasks that analysts can own.

Everest

YCombinator

Everest is an innovative startup in the tech space.

Exonic

YCombinator

Unsupervised Biological AI

What if you could train a biological foundation model on... the entire internet? Exonic is pioneering a new generation of biological foundation models, focused on heterogeneous, unstructured, and noisy datasets. Our first application is the design of safer gene therapies. In 2025, we used AI to set a new state of the art in liver cancer targeted gene therapy, validated in vitro in our lab in San Francisco. So far in 2026, we have trained a new model with unprecedented zero-shot generalization on genomic regulatory expression in hold-out biosample datasets. More to be shared soon.

Expanse

YCombinator

Unlock wasted GPU capacity.

Expanse unlocks wasted GPU capacity. We recover idle compute through three capabilities: resource prediction (right-sizing job submissions before they reach the scheduler), optimisation suggestions (code and config changes researchers can apply themselves), and failure prediction (catching jobs that will fail before they consume hours of GPU time). We’re four engineers. We ran HPC and GPU training workloads at the largest quant funds and national supercomputing centres. We faced this problem first hand and the only fix was to over-provision and burn millions. Ismaeel built the first multimodal HPC resource predictor as research at EPCC (Edinburgh’s Parallel Computing Centre), which beat every published baseline. This is the tool we wish we had.