Discover the next generation of startups.

OpenWork

YCombinator

The open source alternative to Claude Cowork

OpenWork is a desktop app that lets people connect to their existing skills, MCPs, and agents. Users can download the app for free, try it with over 50+ model providers, and easily share their setup with their team.

Operon

YCombinator

Agentic data layer for manufacturing & process industries.

Operon is the data intelligence layer for heavy industry. We ingest the messy documents a plant runs on (P&IDs, schematics, datasheets, scans) and turn them into one structured, queryable model of the facility. On top of it, engineers query their plant in natural language and build agentic workflows for safety, compliance, and design.

Optimizely

YCombinator

The first all-in-one operating system for marketing

At Optimizely, we're on a mission to help people unlock their digital potential. We do that by reinventing how marketing and product teams work to create and optimize digital experiences across all channels. With Optimizely One, our industry-first operating system for marketers, we offer teams flexibility and choice to build their stack their way with our fully SaaS, fully decoupled, and highly composable solution. We help companies around the world orchestrate their entire content lifecycle, monetize every digital experience and experiment across all customer touchpoints – all through Optimizely One, the leading digital experience platform that powers every phase of the marketing lifecycle through a single, AI-accelerated workflow. Optimizely has nearly 1500 employees across our 21 global offices and has 700+ partners. We are proud to help more than 10,000 businesses, including H&M, PayPal, Zoom, and Toyota, enrich their customer lifetime value, increase revenue and grow their brands. At Optimizely, we live each day with a simple philosophy: large enough to serve, small enough to care. Learn more at optimizely.com.

Origami Robotics

YCombinator

Manipulate Anything Robot

We are building a "manipulate anything" model with the robot hardware that embodies it. We designed a hand-based data-collection device and a high DOF, direct drive robotic hand that match each other exactly, enabling us to eliminate embodiment gap and collect real-world data and deploy it directly. We want to scale real world manipulation data by deploying our devices "in the wild" like manufacturing factories, logistic centers to collect Tesla like data, use these data to train our model and then provide automation solutions to these industries.

Origin

YCombinator

AI and Data for Cancer Therapeutics

Creating the largest patient-derived cancer single-cell dataset for licensing to pharmaceutical and AI companies. These datasets are unique as they screen the effects of various drugs and genetic medicines under the control of our DNA switches.

Ornadyne

YCombinator

We're building robot birds for surveillance.

Ornadyne builds flapping-wing drones for reconnaissance that look, fly, and sound like birds. Today’s drones are easy to detect acoustically, visually, and electronically. As counter-UAS systems improve, traditional quadcopters and fixed-wing UAS systems are becoming increasingly ineffective for close-range surveillance. Flapping-wing aircraft have existed for years, but have lacked the performance, endurance, and control required for real-world deployment. We’re changing that by engineering a high-performance, stealth-optimized system built from first principles for efficiency, autonomy, and reliable field use. The final frontier of surveillance won’t look like machines; it will look like wildlife already in the sky. Maybe birds aren't real?

OS3

YCombinator

Intelligence and Machines for Physical Labor

Semi-humanoid robots that do real physical labor. Building hardware and training models, each driving the other. Already deploying in hospitality.

Osmaura

YCombinator

We find new matter opportunities for corporate law firms.

As soon as a lawyer is made partner, they’re expected to bring in new business. However, it’s often not clear when a company is going to need legal counsel. So partners are encouraged to do business development with every person in their network in hopes that at least one of them generates new work. Osmaura gives partners a deeper understanding of prospective clients and legal support they might need at the right time. Our agents do this by monitoring the web, news, socials, and internal firm context to surface targeted matter opportunities for each partner.

Osseus

YCombinator

The secure research brain for accelerating R&D

Osseus is the secure research brain for R&D teams. Today, research knowledge is fragmented across specialist tools, decisions, conversations, and people's heads. Osseus crafts this into a permissioned memory that grows with every experiment, decision, failure, and lesson learned. Rather than only retrieving the current state of connected tools, Osseus preserves how work evolved: what was tried, what failed, why decisions were made, and who holds the relevant context. Each person gets a personal AI agent that uses this growing history to proactively surface relevant evidence, help prevent duplicated work and repeated mistakes, and identify the exact expert who can unblock the next decision. By preserving both technical history and the organizational know-how behind team processes and decision making, Osseus helps R&D teams move faster before time and money are wasted.